Abstract No. 316 Transcriptional Analysis in a Novel Porcine Model Validates Similarity with Aggressive Subtypes of Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with critical need for novel therapies. Preclinical models that recapitulate the molecular features of human HCC are crucial for evaluating new therapies. As interventional oncology therapies, such as transarterial chemoembolization (TACE), are widely used in HCC management, the demand for large animal models capable of testing these modalities has increased. Pigs are an ideal model due to their similarities to humans in anatomy, physiology, and immune response.
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Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with critical need for novel therapies. Preclinical models that recapitulate the molecular features of human HCC are crucial for evaluating new therapies. As interventional oncology therapies, such as transarterial chemoembolization (TACE), are widely used in HCC management, the demand for large animal models capable of testing these modalities has increased. Pigs are an ideal model due to their similarities to humans in anatomy, physiology, and immune response.
