Abstract No. 228 Single-Center Experience Utilizing Pulse Electrical Field Ablation with and without Concurrent Immunotherapy as Salvage Therapy

Immunotherapy is a promising therapeutic option for cancer, but not all patients respond to immunotherapy alone. Pulsed electric field ablation (PEF) is a novel non-thermal ablation modality inducing cell death through irreversible electroporation. Tumoral neoantigens and damage-associated molecular patterns are subsequently released stimulating the immune response against tumor both locally and distally through an abscopal effect as seen in pre-clinical models. PEF does not alter the tumor antigens which allows an increased adaptive immune response.